[2.2]Paracyclophane‐Based TCN‐201 Analogs as GluN2A‐Selective NMDA Receptor Antagonists

Recent studies have shown the involvement of GluN2A subunit‐containing NMDA receptors in various neurological and pathological disorders. In the X‐ray crystal structure, TCN‐201 (1) and analogous pyrazine derivatives 2 and 3 adopt a U‐shape (hairpin) conformation within the binding site formed by th...

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Detalles Bibliográficos
Autores principales: Rajan, Remya, Schepmann, Dirk, Steigerwald, Ruben, Schreiber, Julian A., El‐Awaad, Ehab, Jose, Joachim, Seebohm, Guiscard, Wünsch, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596836/
https://www.ncbi.nlm.nih.gov/pubmed/34265163
http://dx.doi.org/10.1002/cmdc.202100400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596836/
https://www.ncbi.nlm.nih.gov/pubmed/34265163
http://dx.doi.org/10.1002/cmdc.202100400

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