Xylose‐Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase

Glucocerebrosidase (GBA), a lysosomal retaining β‐d‐glucosidase, has recently been shown to hydrolyze β‐d‐xylosides and to transxylosylate cholesterol. Genetic defects in GBA cause the lysosomal storage disorder Gaucher disease (GD), and also constitute a risk factor for developing Parkinson's...

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Detalles Bibliográficos
Autores principales: Su, Qin, Schröder, Sybrin P., Lelieveld, Lindsey T., Ferraz, Maria J., Verhoek, Marri, Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G., Artola, Marta, Kuo, Chi‐Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596838/
https://www.ncbi.nlm.nih.gov/pubmed/34459538
http://dx.doi.org/10.1002/cbic.202100396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596838/
https://www.ncbi.nlm.nih.gov/pubmed/34459538
http://dx.doi.org/10.1002/cbic.202100396

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