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Potent Tau Aggregation Inhibitor D‐Peptides Selected against Tau‐Repeat 2 Using Mirror Image Phage Display

Alzheimer's disease and other Tauopathies are associated with neurofibrillary tangles composed of Tau protein, as well as toxic Tau oligomers. Therefore, inhibitors of pathological Tau aggregation are potentially useful candidates for future therapies targeting Tauopathies. Two hexapeptides wit...

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Detalles Bibliográficos
Autores principales: Malhis, Marwa, Kaniyappan, Senthilvelrajan, Aillaud, Isabelle, Chandupatla, Ram Reddy, Ramirez, Lisa Marie, Zweckstetter, Markus, Horn, Anselm H. C., Mandelkow, Eckhard, Sticht, Heinrich, Funke, Susanne Aileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8596876/
https://www.ncbi.nlm.nih.gov/pubmed/34375027
http://dx.doi.org/10.1002/cbic.202100287