Physiologically‐Based Pharmacokinetic Modeling to Support the Clinical Management of Drug–Drug Interactions With Bictegravir

Bictegravir is equally metabolized by cytochrome P450 (CYP)3A and uridine diphosphate‐glucuronosyltransferase (UGT)1A1. Drug–drug interaction (DDI) studies were only conducted for strong inhibitors and inducers, leading to some uncertainty whether moderate perpetrators or multiple drug associations...

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Detalles Bibliográficos
Autores principales: Stader, Felix, Battegay, Manuel, Marzolini, Catia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597021/
https://www.ncbi.nlm.nih.gov/pubmed/33626178
http://dx.doi.org/10.1002/cpt.2221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597021/
https://www.ncbi.nlm.nih.gov/pubmed/33626178
http://dx.doi.org/10.1002/cpt.2221

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