Exploration of Pyrazolo[1,5‐a]pyrimidines as Membrane‐Bound Pyrophosphatase Inhibitors

Inhibition of membrane‐bound pyrophosphatase (mPPase) with small molecules offer a new approach in the fight against pathogenic protozoan parasites. mPPases are absent in humans, but essential for many protists as they couple pyrophosphate hydrolysis to the active transport of protons or sodium ions...

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Detalles Bibliográficos
Autores principales: Johansson, Niklas G., Dreano, Loïc, Vidilaseris, Keni, Khattab, Ayman, Liu, Jianing, Lasbleiz, Arthur, Ribeiro, Orquidea, Kiriazis, Alexandros, Boije af Gennäs, Gustav, Meri, Seppo, Goldman, Adrian, Yli‐Kauhaluoma, Jari, Xhaard, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597055/
https://www.ncbi.nlm.nih.gov/pubmed/34459148
http://dx.doi.org/10.1002/cmdc.202100392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597055/
https://www.ncbi.nlm.nih.gov/pubmed/34459148
http://dx.doi.org/10.1002/cmdc.202100392

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