NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome

BACKGROUND: Fragile X syndrome (FXS) is an intellectual disability attributable to loss of fragile X protein (FMRP). We previously demonstrated that FMRP binds mRNAs targeted for nonsense-mediated mRNA decay (NMD) and that FMRP loss results in hyperactivated NMD and inhibition of neuronal differenti...

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Detalles Bibliográficos
Autores principales: Kurosaki, Tatsuaki, Sakano, Hitomi, Pröschel, Christoph, Wheeler, Jason, Hewko, Alexander, Maquat, Lynne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597091/
https://www.ncbi.nlm.nih.gov/pubmed/34784943
http://dx.doi.org/10.1186/s13059-021-02530-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597091/
https://www.ncbi.nlm.nih.gov/pubmed/34784943
http://dx.doi.org/10.1186/s13059-021-02530-9

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