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NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome

BACKGROUND: Fragile X syndrome (FXS) is an intellectual disability attributable to loss of fragile X protein (FMRP). We previously demonstrated that FMRP binds mRNAs targeted for nonsense-mediated mRNA decay (NMD) and that FMRP loss results in hyperactivated NMD and inhibition of neuronal differenti...

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Detalles Bibliográficos
Autores principales:	Kurosaki, Tatsuaki, Sakano, Hitomi, Pröschel, Christoph, Wheeler, Jason, Hewko, Alexander, Maquat, Lynne E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597091/ https://www.ncbi.nlm.nih.gov/pubmed/34784943 http://dx.doi.org/10.1186/s13059-021-02530-9

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