Single‐ and Multiple‐Dose Pharmacokinetics and Pharmacodynamics of PN‐943, a Gastrointestinal‐Restricted Oral Peptide Antagonist of α4β7, in Healthy Volunteers

PN‐943 is an orally stable, gastrointestinal‐restricted peptide that binds specifically to α4ß7 integrin on leukocytes, blocking leukocyte trafficking to and activation in the gut, inhibiting colon inflammation and reducing signs and symptoms of active ulcerative colitis. Two pharmacokinetic/pharmac...

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Detalles Bibliográficos
Autores principales: Modi, Nishit B., Cheng, Xiaoli, Mattheakis, Larry, Hwang, Ching‐Chang, Nawabi, Roya, Liu, David, Gupta, Suneel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597174/
https://www.ncbi.nlm.nih.gov/pubmed/33942566
http://dx.doi.org/10.1002/cpdd.946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597174/
https://www.ncbi.nlm.nih.gov/pubmed/33942566
http://dx.doi.org/10.1002/cpdd.946

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