Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe

Ubiquitin carboxy-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme (DUB), is a potential drug target in various cancers, and liver and lung fibrosis. However, bona fide functions and substrates of UCHL1 remain poorly understood. Herein, we report the characterization of UCHL1 covalent inhibi...

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Detalles Bibliográficos
Autores principales: Panyain, Nattawadee, Godinat, Aurélien, Thawani, Aditya Raymond, Lachiondo-Ortega, Sofía, Mason, Katie, Elkhalifa, Sarah, Smith, Lisa M., Harrigan, Jeanine A., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597422/
https://www.ncbi.nlm.nih.gov/pubmed/34820624
http://dx.doi.org/10.1039/d1md00218j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597422/
https://www.ncbi.nlm.nih.gov/pubmed/34820624
http://dx.doi.org/10.1039/d1md00218j

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