Gepotidacin Pharmacokinetics-Pharmacodynamics against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems

Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action with an in vitro spectrum of activity that includes Escherichia coli. Our objectives herein were the following: (i) to identify the pharmacokinetic-pharmac...

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Detalles Bibliográficos
Autores principales: VanScoy, Brian D., Lakota, Elizabeth A., Conde, Haley, Fikes, Steven, Bhavnani, Sujata M., Elefante, Philippa B., Scangarella-Oman, Nicole E., Ambrose, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597728/
https://www.ncbi.nlm.nih.gov/pubmed/34543096
http://dx.doi.org/10.1128/AAC.00122-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597728/
https://www.ncbi.nlm.nih.gov/pubmed/34543096
http://dx.doi.org/10.1128/AAC.00122-21

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