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Gepotidacin Pharmacokinetics-Pharmacodynamics against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems

Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action with an in vitro spectrum of activity that includes Escherichia coli. Our objectives herein were the following: (i) to identify the pharmacokinetic-pharmac...

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Detalles Bibliográficos
Autores principales:	VanScoy, Brian D., Lakota, Elizabeth A., Conde, Haley, Fikes, Steven, Bhavnani, Sujata M., Elefante, Philippa B., Scangarella-Oman, Nicole E., Ambrose, Paul G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597728/ https://www.ncbi.nlm.nih.gov/pubmed/34543096 http://dx.doi.org/10.1128/AAC.00122-21

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