Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications

Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel therapeutic compounds. However, interspecies differences in the mechanisms regulating excitation-contraction coupling can limit the translation of experimental findings from animal models to human physiology and...

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Detalles Bibliográficos
Autores principales: Morotti, Stefano, Liu, Caroline, Hegyi, Bence, Ni, Haibo, Fogli Iseppe, Alex, Wang, Lianguo, Pritoni, Marco, Ripplinger, Crystal M., Bers, Donald M., Edwards, Andrew G., Grandi, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598003/
https://www.ncbi.nlm.nih.gov/pubmed/34788089
http://dx.doi.org/10.1126/sciadv.abg0927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598003/
https://www.ncbi.nlm.nih.gov/pubmed/34788089
http://dx.doi.org/10.1126/sciadv.abg0927

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