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Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel therapeutic compounds. However, interspecies differences in the mechanisms regulating excitation-contraction coupling can limit the translation of experimental findings from animal models to human physiology and...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598003/ https://www.ncbi.nlm.nih.gov/pubmed/34788089 http://dx.doi.org/10.1126/sciadv.abg0927 |