mTOR-dependent translation drives tumor infiltrating CD8(+) effector and CD4(+) Treg cells expansion

We performed a systematic analysis of the translation rate of tumor-infiltrating lymphocytes (TILs) and the microenvironment inputs affecting it, both in humans and in mice. Measurement of puromycin incorporation, a proxy of protein synthesis, revealed an increase of translating CD4(+) and CD8(+) ce...

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Detalles Bibliográficos
Autores principales: De Ponte Conti, Benedetta, Miluzio, Annarita, Grassi, Fabio, Abrignani, Sergio, Biffo, Stefano, Ricciardi, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598161/
https://www.ncbi.nlm.nih.gov/pubmed/34787568
http://dx.doi.org/10.7554/eLife.69015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598161/
https://www.ncbi.nlm.nih.gov/pubmed/34787568
http://dx.doi.org/10.7554/eLife.69015

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