Cargando…

mTOR-dependent translation drives tumor infiltrating CD8(+) effector and CD4(+) Treg cells expansion

We performed a systematic analysis of the translation rate of tumor-infiltrating lymphocytes (TILs) and the microenvironment inputs affecting it, both in humans and in mice. Measurement of puromycin incorporation, a proxy of protein synthesis, revealed an increase of translating CD4(+) and CD8(+) ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Ponte Conti, Benedetta, Miluzio, Annarita, Grassi, Fabio, Abrignani, Sergio, Biffo, Stefano, Ricciardi, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598161/ https://www.ncbi.nlm.nih.gov/pubmed/34787568 http://dx.doi.org/10.7554/eLife.69015

Ejemplares similares

Treg and Oligoclonal Expansion of Terminal Effector CD8(+) T Cell as Key Players in Multiple Myeloma
por: Joshua, Douglas E., et al.
Publicado: (2021)

Translational Control of Metabolism and Cell Cycle Progression in Hepatocellular Carcinoma
por: Scagliola, Alessandra, et al.
Publicado: (2023)

CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion
por: Rose, Marie-Clare St., et al.
Publicado: (2013)

Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling
por: Agliano, Federica, et al.
Publicado: (2022)

Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study
por: Scagliola, Alessandra, et al.
Publicado: (2022)

Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection
por: Thorborn, Georgina, et al.
Publicado: (2010)

CD4(+)CCR8(+) Tregs in ovarian cancer: a potential effector Tregs for immune regulation
por: Liu, Shuna, et al.
Publicado: (2023)

Translating the Game: Ribosomes as Active Players
por: Calamita, Piera, et al.
Publicado: (2018)

Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs
por: Bowakim-Anta, Natalia, et al.
Publicado: (2023)

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127(pos) Depletion, Treg Expansion, and Treg Cryopreservation
por: Peters, Jorieke H., et al.
Publicado: (2008)

Glucose metabolism and function of CD4 (+) Tregs are regulated by the TLR8/mTOR signal in an environment of SKOV3 cell growth
por: Wu, Ming, et al.
Publicado: (2023)

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo
por: Miluzio, Annarita, et al.
Publicado: (2015)

The Translational Machinery of Human CD4(+) T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling
por: Ricciardi, Sara, et al.
Publicado: (2018)

mTOR regulates memory CD8 T cell differentiation
por: Araki, Koichi, et al.
Publicado: (2009)

Regulation of CD8(+) T memory and exhaustion by the mTOR signals
por: Chen, Yao, et al.
Publicado: (2023)

In Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4(+)CD25(−) Cells in Mice
por: Arazi, Arnon, et al.
Publicado: (2009)

Circulating CD4(+) Treg, CD8(+) Treg, and CD3(+) γδ T Cell Subpopulations in Ovarian Cancer
por: Li, Rong, et al.
Publicado: (2023)

Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2
por: Miluzio, Annarita, et al.
Publicado: (2022)

CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures
por: Nowak, Anna, et al.
Publicado: (2018)

High Thymic Output of Effector CD4(+) Cells May Lead to a Treg : T Effector Imbalance in the Periphery in NOD Mice
por: Zhao, Yuan, et al.
Publicado: (2019)

Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis
por: Li, Wenli, et al.
Publicado: (2021)

The correlation between infiltration of FoxP3(+) Tregs, CD66b(+) TANs and CD163(+) TAMs in colorectal cancer
por: Ren, Yuehan, et al.
Publicado: (2022)

Tolerogenic Vaccination Reduced Effector Memory CD4 T Cells and Induced Effector Memory Treg Cells for Type I Diabetes Treatment
por: Zhang, Jingyao, et al.
Publicado: (2013)

Hepatitis B envelope antigen increases Tregs by converting CD4+CD25(-) T cells into CD4(+)CD25(+)Foxp3(+) Tregs
por: Tang, Rui, et al.
Publicado: (2020)

mTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4(+) T cell immune response in acute pancreatitis
por: Xu, Dan, et al.
Publicado: (2020)

mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases
por: Jiang, Qian, et al.
Publicado: (2022)

Author Correction: Regulation of CD8(+) T memory and exhaustion by the mTOR signals
por: Chen, Yao, et al.
Publicado: (2023)

CD4+CD25+CD127-Foxp3+ and CD8+CD28- Tregs in Renal Transplant Recipients: Phenotypic Patterns, Association With Immunosuppressive Drugs, and Interaction With Effector CD8+ T Cells and CD19+IL-10+ Bregs
por: Aly, Mostafa G., et al.
Publicado: (2021)

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma
por: Mandapathil, Magis, et al.
Publicado: (2012)

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios(+) T cells and autoantibodies
por: Daley, Stephen R, et al.
Publicado: (2013)

mTOR Inhibition Impairs the Activation and Function of Belatacept-Resistant CD4(+)CD57(+) T Cells In Vivo and In Vitro
por: Herr, Florence, et al.
Publicado: (2023)

Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA
por: Tian, Yuan, et al.
Publicado: (2017)

Human CD4(+)CD25(+)CD226(-) Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4(+)CD25(+)CD127(lo/-) Tregs for Adoptive Cell Therapy
por: Brown, Matthew E., et al.
Publicado: (2022)

Inflammation-Driven Reprogramming of CD4(+)Foxp3(+) Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTOR Inhibition in vivo
por: Yurchenko, Ekaterina, et al.
Publicado: (2012)

Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity
por: Ratzinger, F., et al.
Publicado: (2014)

Resident-Memory CD8 T Cells and mTOR: Generation, Protection, and Clinical Importance
por: Sowell, Ryan T., et al.
Publicado: (2015)

The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4(+) T Cell Subsets
por: Wang, Peng, et al.
Publicado: (2020)

mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis
por: Wang, Hao, et al.
Publicado: (2018)

mTOR Regulation of Metabolism in Hematologic Malignancies
por: Mirabilii, Simone, et al.
Publicado: (2020)

Biological Aspects of mTOR in Leukemia
por: Mirabilii, Simone, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hkrcgs60sjrqj182hipj7plhf3