A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

Cytokine-mediated activation of host immunity is central to the control of pathogens. Interferon-gamma (IFNγ) is a key cytokine in protective immunity that induces major histocompatibility complex class II molecules (MHCII) to amplify CD4(+) T cell activation and effector function. Despite its centr...

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Detalles Bibliográficos
Autores principales: Kiritsy, Michael C, Ankley, Laurisa M, Trombley, Justin, Huizinga, Gabrielle P, Lord, Audrey E, Orning, Pontus, Elling, Roland, Fitzgerald, Katherine A, Olive, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598162/
https://www.ncbi.nlm.nih.gov/pubmed/34747695
http://dx.doi.org/10.7554/eLife.65110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598162/
https://www.ncbi.nlm.nih.gov/pubmed/34747695
http://dx.doi.org/10.7554/eLife.65110

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