Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

Pancreatic cancer has a high mortality rate due to metastasis. Whereas KRAS is mutated in most pancreatic cancer patients, controlling KRAS or its downstream effectors has not been succeeded clinically. ARL4C is a small G protein whose expression is induced by the Wnt and EGF–RAS pathways. In the pr...

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Detalles Bibliográficos
Autores principales: Harada, Akikazu, Matsumoto, Shinji, Yasumizu, Yoshiaki, Shojima, Kensaku, Akama, Toshiyuki, Eguchi, Hidetoshi, Kikuchi, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598236/
https://www.ncbi.nlm.nih.gov/pubmed/34590580
http://dx.doi.org/10.7554/eLife.66721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598236/
https://www.ncbi.nlm.nih.gov/pubmed/34590580
http://dx.doi.org/10.7554/eLife.66721

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