Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

Compounds targeting the inflammasome-caspase-1 pathway could be of use for the treatment of inflammation and inflammatory diseases. Previous caspase-1 inhibitors were in great majority covalent inhibitors and failed in clinical trials. Using a mixed modelling, computational screening, synthesis and...

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Detalles Bibliográficos
Autores principales: Ulgheri, Fausta, Spanu, Pietro, Deligia, Francesco, Loriga, Giovanni, Fuggetta, Maria Pia, de Haan, Iris, Chandgudge, Ajay, Groves, Matthew, Domling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598261/
https://www.ncbi.nlm.nih.gov/pubmed/34823899
http://dx.doi.org/10.1016/j.ejmech.2021.114002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598261/
https://www.ncbi.nlm.nih.gov/pubmed/34823899
http://dx.doi.org/10.1016/j.ejmech.2021.114002

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