Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice

CRISPR-Cas systems have emerged as a powerful tool to generate genetic models for studying normal and diseased central nervous system (CNS). Targeted gene disruption at specific loci has been demonstrated successfully in non-dividing neurons. Despite its simplicity, high specificity and low cost, th...

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Detalles Bibliográficos
Autores principales: Hana, Sam, Peterson, Michael, McLaughlin, Helen, Marshall, Eric, Fabian, Attila J., McKissick, Olivia, Koszka, Kathryn, Marsh, Galina, Craft, Michael, Xu, Shanqin, Sorets, Alexander, Torregrosa, Tess, Sun, Chao, Henderson, Chris E., Lo, Shih-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599009/
https://www.ncbi.nlm.nih.gov/pubmed/33558692
http://dx.doi.org/10.1038/s41434-021-00224-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599009/
https://www.ncbi.nlm.nih.gov/pubmed/33558692
http://dx.doi.org/10.1038/s41434-021-00224-2

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