An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T)

BACKGROUND: ATM, the protein defective in the human genetic disorder, ataxia-telangiectasia (A-T) plays a central role in response to DNA double-strand breaks (DSBs) and in protecting the cell against oxidative stress. We showed that A-T cells are hypersensitive to metabolic stress which can be acco...

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Detalles Bibliográficos
Autores principales: Yeo, A.J., Subramanian, G.N., Chong, K.L., Gatei, M., Parton, R.G., Coman, D., Lavin, M.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599162/
https://www.ncbi.nlm.nih.gov/pubmed/34637921
http://dx.doi.org/10.1016/j.molmet.2021.101354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599162/
https://www.ncbi.nlm.nih.gov/pubmed/34637921
http://dx.doi.org/10.1016/j.molmet.2021.101354

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