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An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T)
BACKGROUND: ATM, the protein defective in the human genetic disorder, ataxia-telangiectasia (A-T) plays a central role in response to DNA double-strand breaks (DSBs) and in protecting the cell against oxidative stress. We showed that A-T cells are hypersensitive to metabolic stress which can be acco...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599162/ https://www.ncbi.nlm.nih.gov/pubmed/34637921 http://dx.doi.org/10.1016/j.molmet.2021.101354 |