SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

The nuclear RNA-binding protein TDP-43 forms abnormal cytoplasmic aggregates in the brains of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients and several molecular mechanisms promoting TDP-43 cytoplasmic mislocalization and aggregation have been proposed, including def...

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Detalles Bibliográficos
Autores principales: Maraschi, AnnaMaria, Gumina, Valentina, Dragotto, Jessica, Colombrita, Claudia, Mompeán, Miguel, Buratti, Emanuele, Silani, Vincenzo, Feligioni, Marco, Ratti, Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599232/
https://www.ncbi.nlm.nih.gov/pubmed/34390468
http://dx.doi.org/10.1007/s12035-021-02505-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599232/
https://www.ncbi.nlm.nih.gov/pubmed/34390468
http://dx.doi.org/10.1007/s12035-021-02505-8

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