A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity

BACKGROUND: The interaction of small molecules with direct targets constitutes the molecular initiation events of drug efficacy and toxicity. Aconitine, an active compound of the Aconitum species, has various pharmacological effects but is strongly toxic to the heart. The direct targets of aconitine...

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Detalles Bibliográficos
Autores principales: Wei, Jinxia, Fan, Simiao, Yu, Hongxin, Shu, Lexin, Li, Yubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599306/
https://www.ncbi.nlm.nih.gov/pubmed/34803375
http://dx.doi.org/10.2147/DDDT.S335461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599306/
https://www.ncbi.nlm.nih.gov/pubmed/34803375
http://dx.doi.org/10.2147/DDDT.S335461

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