Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model

De novo loss‐of‐function mutations in methyl‐CpG‐binding protein 2 (MeCP2) lead to the neurodevelopmental disorder Rett syndrome (RTT). Despite promising results from strategies aimed at increasing MeCP2 levels, additional studies exploring how hypomorphic MeCP2 mutations impact the therapeutic wind...

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Detalles Bibliográficos
Autores principales: Vermudez, Sheryl Anne D., Gogliotti, Rocco G., Arthur, Bright, Buch, Aditi, Morales, Clarissa, Moxley, Yuta, Rajpal, Hemangi, Conn, P. Jeffrey, Niswender, Colleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599502/
https://www.ncbi.nlm.nih.gov/pubmed/34002468
http://dx.doi.org/10.1111/gbb.12752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599502/
https://www.ncbi.nlm.nih.gov/pubmed/34002468
http://dx.doi.org/10.1111/gbb.12752

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