Negative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time

Protein-mediated DNA looping is fundamental to gene regulation and such loops occur stochastically in purified systems. Additional proteins increase the probability of looping, but these probabilities maintain a broad distribution. For example, the probability of lac repressor-mediated looping in in...

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Detalles Bibliográficos
Autores principales: Yan, Yan, Xu, Wenxuan, Kumar, Sandip, Zhang, Alexander, Leng, Fenfei, Dunlap, David, Finzi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599721/
https://www.ncbi.nlm.nih.gov/pubmed/34723343
http://dx.doi.org/10.1093/nar/gkab946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599721/
https://www.ncbi.nlm.nih.gov/pubmed/34723343
http://dx.doi.org/10.1093/nar/gkab946

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