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Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery

Prime editing is a recent precision genome editing modality whose versatility offers the prospect for a wide range of applications, including the development of targeted genetic therapies. Yet, an outstanding bottleneck for its optimization and use concerns the difficulty in delivering large prime e...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Liu, Jin, Janssen, Josephine M, Tasca, Francesca, Mei, Hailiang, Gonçalves, Manuel A F V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599732/
https://www.ncbi.nlm.nih.gov/pubmed/34669958
http://dx.doi.org/10.1093/nar/gkab938