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Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery
Prime editing is a recent precision genome editing modality whose versatility offers the prospect for a wide range of applications, including the development of targeted genetic therapies. Yet, an outstanding bottleneck for its optimization and use concerns the difficulty in delivering large prime e...
Autores principales: | Wang, Qian, Liu, Jin, Janssen, Josephine M, Tasca, Francesca, Mei, Hailiang, Gonçalves, Manuel A F V |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599732/ https://www.ncbi.nlm.nih.gov/pubmed/34669958 http://dx.doi.org/10.1093/nar/gkab938 |
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