Cargando…

MicroDNA levels are dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA damage

Extrachromosomal circular DNA (eccDNA) are present within all eukaryotic organisms and actively contribute to gene expression changes. MicroDNA (200-1000bp) are the most abundant type of eccDNA and can amplify tRNA, microRNA, and novel si-like RNA sequences. Due to the heterogeneity of microDNA and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paulsen, Teressa, Malapati, Pumoli, Shibata, Yoshiyuki, Wilson, Briana, Eki, Rebeka, Benamar, Mouadh, Abbas, Tarek, Dutta, Anindya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599734/ https://www.ncbi.nlm.nih.gov/pubmed/34718766 http://dx.doi.org/10.1093/nar/gkab984

Ejemplares similares

Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters
por: Paulsen, Teressa, et al.
Publicado: (2019)

A robust CRISPR–Cas9-based fluorescent reporter assay for the detection and quantification of DNA double-strand break repair
por: Eki, Rebeka, et al.
Publicado: (2020)

Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing
por: Fu, Ya-Wen, et al.
Publicado: (2021)

Characterization of the microDNA through the response to chemotherapeutics in lymphoblastoid cell lines
por: Mehanna, Pamela, et al.
Publicado: (2017)

ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines
por: Kumar, Pankaj, et al.
Publicado: (2020)

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis
por: Jiang, Rong, et al.
Publicado: (2023)

Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks
por: Khodaverdian, Varandt Y., et al.
Publicado: (2017)

DNA-PK(cs)-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
por: Lu, Huiming, et al.
Publicado: (2022)

Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei
por: Sun, Teng, et al.
Publicado: (2019)

DNA-binding determinants promoting NHEJ by human Polµ
por: Martin, Maria Jose, et al.
Publicado: (2012)

Detection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPET
por: Shibata, Yoshiyuki, et al.
Publicado: (2010)

Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ
por: Aida, Tomomi, et al.
Publicado: (2016)

Stress-inducible NHEJ in bacteria: function in DNA repair and acquisition of heterologous DNA
por: Dupuy, Pierre, et al.
Publicado: (2019)

Analysis of NHEJ-Based DNA Repair after CRISPR-Mediated DNA Cleavage
por: Song, Beomjong, et al.
Publicado: (2021)

Molecular basis for DNA strand displacement by NHEJ repair polymerases
por: Bartlett, Edward J., et al.
Publicado: (2016)

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
por: Chaplin, Amanda K., et al.
Publicado: (2021)

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ
por: Chen, Siyu, et al.
Publicado: (2023)

Two subunits of human ORC are dispensable for DNA replication and proliferation
por: Shibata, Etsuko, et al.
Publicado: (2016)

Structural insights into the role of DNA-PK as a master regulator in NHEJ
por: Chen, Siyu, et al.
Publicado: (2021)

Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase
por: Brissett, Nigel C., et al.
Publicado: (2013)

CATI: an efficient gene integration method for rodent and primate embryos by MMEJ suppression
por: Chen, Hongyu, et al.
Publicado: (2023)

Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN
por: Arnoult, Nausica, et al.
Publicado: (2017)

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
por: Zhao, Bailin, et al.
Publicado: (2019)

Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments
por: Yanik, Mert, et al.
Publicado: (2018)

The DNA polymerase λ is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells
por: Capp, Jean-Pascal, et al.
Publicado: (2006)

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks
por: Britton, Sébastien, et al.
Publicado: (2020)

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
por: Kim, Jong-Soo, et al.
Publicado: (2005)

Multiple and Variable NHEJ-Like Genes Are Involved in Resistance to DNA Damage in Streptomyces ambofaciens
por: Hoff, Grégory, et al.
Publicado: (2016)

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
por: Zelensky, Alex N., et al.
Publicado: (2017)

TBX20 inhibits colorectal cancer tumorigenesis by impairing NHEJ‐mediated DNA repair
por: Luo, Jie, et al.
Publicado: (2022)

Uncovering the Molecular Drivers of NHEJ DNA Repair-Implicated Missense Variants and Their Functional Consequences
por: Al-Jarf, Raghad, et al.
Publicado: (2023)

Deploying MMEJ using MENdel in precision gene editing applications for gene therapy and functional genomics
por: Martínez-Gálvez, Gabriel, et al.
Publicado: (2020)

Ligation-assisted homologous recombination enables precise genome editing by deploying both MMEJ and HDR
por: Zhao, Zhihan, et al.
Publicado: (2022)

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
por: Wang, Minli, et al.
Publicado: (2006)

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency
por: Chang, Howard H. Y., et al.
Publicado: (2016)

Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion
por: Chatla, Srinivas, et al.
Publicado: (2019)

PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair
por: Pan, Qimei, et al.
Publicado: (2023)

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma
por: Benamar, Mouadh, et al.
Publicado: (2016)

Repair of chromosomal breaks by NHEJ
por: Reid, Dylan A., et al.
Publicado: (2015)

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86
por: Beskow, C, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_uf917uhop95pcd5m8j1tnmm4md