Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal organ precursors. Using a human stem cell model of pancreas differentiation, we here discover that only a subset of pancreatic enhancers is FOXA-primed, whereas the majority is unprimed and engages FOXA upon linea...

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Detalles Bibliográficos
Autores principales: Geusz, Ryan J., Wang, Allen, Lam, Dieter K., Vinckier, Nicholas K., Alysandratos, Konstantinos-Dionysios, Roberts, David A., Wang, Jinzhao, Kefalopoulou, Samy, Ramirez, Araceli, Qiu, Yunjiang, Chiou, Joshua, Gaulton, Kyle J., Ren, Bing, Kotton, Darrell N., Sander, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599738/
https://www.ncbi.nlm.nih.gov/pubmed/34789735
http://dx.doi.org/10.1038/s41467-021-26950-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599738/
https://www.ncbi.nlm.nih.gov/pubmed/34789735
http://dx.doi.org/10.1038/s41467-021-26950-0

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