RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs

RNA-binding proteins regulate mRNA processing and translation and are often aberrantly expressed in cancer. The RNA-binding motif protein 6, RBM6, is a known alternative splicing factor that harbors tumor suppressor activity and is frequently mutated in human cancer. Here, we identify RBM6 as a nove...

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Detalles Bibliográficos
Autores principales: Machour, Feras E, Abu-Zhayia, Enas R, Awwad, Samah W, Bidany-Mizrahi, Tirza, Meinke, Stefan, Bishara, Laila A, Heyd, Florian, Aqeilan, Rami I, Ayoub, Nabieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599755/
https://www.ncbi.nlm.nih.gov/pubmed/34718714
http://dx.doi.org/10.1093/nar/gkab976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599755/
https://www.ncbi.nlm.nih.gov/pubmed/34718714
http://dx.doi.org/10.1093/nar/gkab976

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