Oxidation alters the architecture of the phenylalanyl-tRNA synthetase editing domain to confer hyperaccuracy

High fidelity during protein synthesis is accomplished by aminoacyl-tRNA synthetases (aaRSs). These enzymes ligate an amino acid to a cognate tRNA and have proofreading and editing capabilities that ensure high fidelity. Phenylalanyl-tRNA synthetase (PheRS) preferentially ligates a phenylalanine to...

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Detalles Bibliográficos
Autores principales: Srinivas, Pooja, Steiner, Rebecca E, Pavelich, Ian J, Guerrero-Ferreira, Ricardo, Juneja, Puneet, Ibba, Michael, Dunham, Christine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599791/
https://www.ncbi.nlm.nih.gov/pubmed/34581811
http://dx.doi.org/10.1093/nar/gkab856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599791/
https://www.ncbi.nlm.nih.gov/pubmed/34581811
http://dx.doi.org/10.1093/nar/gkab856

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