High-affinity five/six-letter DNA aptamers with superior specificity enabling the detection of dengue NS1 protein variants beyond the serotype identification

Genetic alphabet expansion of DNA by introducing unnatural bases (UBs), as a fifth letter, dramatically augments the affinities of DNA aptamers that bind to target proteins. To determine whether UB-containing DNA (UB-DNA) aptamers obtained by affinity selection could spontaneously achieve high speci...

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Detalles Bibliográficos
Autores principales: Matsunaga, Ken-ichiro, Kimoto, Michiko, Lim, Vanessa Weixun, Tan, Hui Pen, Wong, Yu Qian, Sun, William, Vasoo, Shawn, Leo, Yee Sin, Hirao, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599795/
https://www.ncbi.nlm.nih.gov/pubmed/34169309
http://dx.doi.org/10.1093/nar/gkab515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599795/
https://www.ncbi.nlm.nih.gov/pubmed/34169309
http://dx.doi.org/10.1093/nar/gkab515

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