7-Aryl-7-deazapurine 3′-deoxyribonucleoside derivative as a novel lead for Chagas’ disease therapy: in vitro and in vivo pharmacology

BACKGROUND: The protozoan Trypanosoma cruzi is auxotrophic for purines and causes Chagas’ disease (CD), a neglected illness affecting >6 million people. Combining the 3-deoxyribofuranose part of cordycepin with the modified purine ring of a nucleoside ‘hit’ led to the discovery of 4-amino-5-(4-ch...

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Detalles Bibliográficos
Autores principales: Cardoso-Santos, Camila, Ferreira de Almeida Fiuza, Ludmila, França da Silva, Cristiane, Mazzeti, Ana Lia, Donola Girão, Roberson, Melo de Oliveira, Gabriel, da Gama Jaen Batista, Denise, Cruz Moreira, Otacilio, Lins da Silva Gomes, Natália, Maes, Louis, Caljon, Guy, Hulpia, Fabian, Calenbergh, Serge V, Correia Soeiro, Maria de Nazaré
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599808/
https://www.ncbi.nlm.nih.gov/pubmed/34806007
http://dx.doi.org/10.1093/jacamr/dlab168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599808/
https://www.ncbi.nlm.nih.gov/pubmed/34806007
http://dx.doi.org/10.1093/jacamr/dlab168

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