Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity

RECQ1 is the shortest among the five human RecQ helicases comprising of two RecA like domains, a zinc-binding domain and a RecQ C-terminal domain containing the winged-helix (WH). Mutations or deletions on the tip of a β-hairpin located in the WH domain are known to abolish the unwinding activity. I...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Swagata, Das, Tulika, Bose, Madhuparna, Jain, Chetan Kumar, Chakraborty, Mayukh, Mukherjee, Sunandan, Shikha, Kumari, Das, Amit K, Ganguly, Agneyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599812/
https://www.ncbi.nlm.nih.gov/pubmed/34751402
http://dx.doi.org/10.1093/nar/gkab968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599812/
https://www.ncbi.nlm.nih.gov/pubmed/34751402
http://dx.doi.org/10.1093/nar/gkab968

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