Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus

The 2A protein of Theiler's murine encephalomyelitis virus (TMEV) acts as a switch to stimulate programmed –1 ribosomal frameshifting (PRF) during infection. Here, we present the X-ray crystal structure of TMEV 2A and define how it recognises the stimulatory RNA element. We demonstrate a critic...

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Detalles Bibliográficos
Autores principales: Hill, Chris H, Cook, Georgia M, Napthine, Sawsan, Kibe, Anuja, Brown, Katherine, Caliskan, Neva, Firth, Andrew E, Graham, Stephen C, Brierley, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599813/
https://www.ncbi.nlm.nih.gov/pubmed/34751406
http://dx.doi.org/10.1093/nar/gkab969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599813/
https://www.ncbi.nlm.nih.gov/pubmed/34751406
http://dx.doi.org/10.1093/nar/gkab969

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