Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer

TGFβ is a potential target in cancer treatment due to its dual role in tumorigenesis and homeostasis. However, the expression of TGFβ and its inhibition within the tumor microenvironment has mainly been investigated in stroma-heavy tumors. Using B16 mouse melanoma and CT26 colon carcinoma as models...

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Detalles Bibliográficos
Autores principales: Gupta, Aditi, Budhu, Sadna, Fitzgerald, Kelly, Giese, Rachel, Michel, Adam O., Holland, Aliya, Campesato, Luis Felipe, van Snick, Jacques, Uyttenhove, Catherine, Ritter, Gerd, Wolchok, Jedd D., Merghoub, Taha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599839/
https://www.ncbi.nlm.nih.gov/pubmed/34789823
http://dx.doi.org/10.1038/s42003-021-02773-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599839/
https://www.ncbi.nlm.nih.gov/pubmed/34789823
http://dx.doi.org/10.1038/s42003-021-02773-z

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