Cooperative methylation of human tRNA(3)(Lys) at positions A58 and U54 drives the early and late steps of HIV-1 replication

Retroviral infection requires reverse transcription, and the reverse transcriptase (RT) uses cellular tRNA as its primer. In humans, the TRMT6-TRMT61A methyltransferase complex incorporates N(1)-methyladenosine modification at tRNA position 58 (m(1)A58); however, the role of m(1)A58 as an RT-stop si...

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Detalles Bibliográficos
Autores principales: Fukuda, Hiroyuki, Chujo, Takeshi, Wei, Fan-Yan, Shi, Sheng-Lan, Hirayama, Mayumi, Kaitsuka, Taku, Yamamoto, Takahiro, Oshiumi, Hiroyuki, Tomizawa, Kazuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599865/
https://www.ncbi.nlm.nih.gov/pubmed/34642752
http://dx.doi.org/10.1093/nar/gkab879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599865/
https://www.ncbi.nlm.nih.gov/pubmed/34642752
http://dx.doi.org/10.1093/nar/gkab879

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