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Cooperative methylation of human tRNA(3)(Lys) at positions A58 and U54 drives the early and late steps of HIV-1 replication
Retroviral infection requires reverse transcription, and the reverse transcriptase (RT) uses cellular tRNA as its primer. In humans, the TRMT6-TRMT61A methyltransferase complex incorporates N(1)-methyladenosine modification at tRNA position 58 (m(1)A58); however, the role of m(1)A58 as an RT-stop si...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599865/ https://www.ncbi.nlm.nih.gov/pubmed/34642752 http://dx.doi.org/10.1093/nar/gkab879 |