Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity

α-Synuclein (αS) has been well-documented to play a role in human synucleinopathies such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). First, the lesions found in PD/DLB brains—Lewy bodies and Lewy neurites—are rich in aggregated αS. Second, genetic evidence links missense mutatio...

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Detalles Bibliográficos
Autores principales: Kim, Tae-Eun, Newman, Andrew J, Imberdis, Thibaut, Brontesi, Lisa, Tripathi, Arati, Ramalingam, Nagendran, Fanning, Saranna, Selkoe, Dennis, Dettmer, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600006/
https://www.ncbi.nlm.nih.gov/pubmed/34254125
http://dx.doi.org/10.1093/hmg/ddab188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600006/
https://www.ncbi.nlm.nih.gov/pubmed/34254125
http://dx.doi.org/10.1093/hmg/ddab188

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