NAD(+) bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells

Elevated expression of the DNA damage response proteins PARP1 and poly(ADP-ribose) glycohydrolase (PARG) in glioma stem cells (GSCs) suggests that glioma may be a unique target for PARG inhibitors (PARGi). While PARGi-induced cell death is achieved when combined with ionizing radiation, as a single...

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Detalles Bibliográficos
Autores principales: Li, Jianfeng, M. Saville, Kate, Ibrahim, Md, Zeng, Xuemei, McClellan, Steve, Angajala, Anusha, Beiser, Alison, Andrews, Joel F, Sun, Mai, Koczor, Christopher A, Clark, Jennifer, Hayat, Faisal, Makarov, Mikhail V, Wilk, Anna, Yates, Nathan A, Migaud, Marie E, Sobol, Robert W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600031/
https://www.ncbi.nlm.nih.gov/pubmed/34806016
http://dx.doi.org/10.1093/narcan/zcab044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600031/
https://www.ncbi.nlm.nih.gov/pubmed/34806016
http://dx.doi.org/10.1093/narcan/zcab044

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