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Investigation of bioluminescence-based assays for determination of kinetic parameters for the bifunctional Neisseria meningitidis serogroup W capsule polymerase

OBJECTIVE: Neisseria meningitidis is a Gram-negative bacterium that causes meningitis. N. meningitidis serogroup W (NmW) capsule polymerase synthesizes capsular polysaccharide of this serogroup. This enzyme could be a tool for meningococcal glycoconjugate vaccine development. Our long-term goal is t...

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Detalles Bibliográficos
Autores principales: Sheikhi Moghaddam, Laleh, Adegbite, Ayobami, McCarthy, Pumtiwitt C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600345/
https://www.ncbi.nlm.nih.gov/pubmed/34794506
http://dx.doi.org/10.1186/s13104-021-05831-1