Affinity Capillary Electrophoresis–Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody–Receptor Interactions

[Image: see text] Monoclonal antibody (mAb) pharmaceuticals consist of a plethora of different proteoforms with different functional characteristics, including pharmacokinetics and pharmacodynamics, requiring their individual assessment. Current binding techniques do not distinguish between coexisti...

Descripción completa

Detalles Bibliográficos
Autores principales: Gstöttner, Christoph, Hook, Michaela, Christopeit, Tony, Knaupp, Alexander, Schlothauer, Tilman, Reusch, Dietmar, Haberger, Markus, Wuhrer, Manfred, Domínguez-Vega, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600502/
https://www.ncbi.nlm.nih.gov/pubmed/34739220
http://dx.doi.org/10.1021/acs.analchem.1c03560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600502/
https://www.ncbi.nlm.nih.gov/pubmed/34739220
http://dx.doi.org/10.1021/acs.analchem.1c03560

Ejemplares similares