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Affinity Capillary Electrophoresis–Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody–Receptor Interactions

[Image: see text] Monoclonal antibody (mAb) pharmaceuticals consist of a plethora of different proteoforms with different functional characteristics, including pharmacokinetics and pharmacodynamics, requiring their individual assessment. Current binding techniques do not distinguish between coexisti...

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Detalles Bibliográficos
Autores principales:	Gstöttner, Christoph, Hook, Michaela, Christopeit, Tony, Knaupp, Alexander, Schlothauer, Tilman, Reusch, Dietmar, Haberger, Markus, Wuhrer, Manfred, Domínguez-Vega, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600502/ https://www.ncbi.nlm.nih.gov/pubmed/34739220 http://dx.doi.org/10.1021/acs.analchem.1c03560

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