B cell depletion impairs vaccination-induced CD8(+) T cell responses in a type I interferon-dependent manner

OBJECTIVES: The monoclonal anti-CD20 antibody rituximab is frequently applied in the treatment of lymphoma as well as autoimmune diseases and confers efficient depletion of recirculating B cells. Correspondingly, B cell-depleted patients barely mount de novo antibody responses during infections or v...

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Detalles Bibliográficos
Autores principales: Graalmann, Theresa, Borst, Katharina, Manchanda, Himanshu, Vaas, Lea, Bruhn, Matthias, Graalmann, Lukas, Koster, Mario, Verboom, Murielle, Hallensleben, Michael, Guzmán, Carlos Alberto, Sutter, Gerd, Schmidt, Reinhold E, Witte, Torsten, Kalinke, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Rheumatoid Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600602/
https://www.ncbi.nlm.nih.gov/pubmed/34226189
http://dx.doi.org/10.1136/annrheumdis-2021-220435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600602/
https://www.ncbi.nlm.nih.gov/pubmed/34226189
http://dx.doi.org/10.1136/annrheumdis-2021-220435

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