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B cell depletion impairs vaccination-induced CD8(+) T cell responses in a type I interferon-dependent manner

OBJECTIVES: The monoclonal anti-CD20 antibody rituximab is frequently applied in the treatment of lymphoma as well as autoimmune diseases and confers efficient depletion of recirculating B cells. Correspondingly, B cell-depleted patients barely mount de novo antibody responses during infections or v...

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Detalles Bibliográficos
Autores principales:	Graalmann, Theresa, Borst, Katharina, Manchanda, Himanshu, Vaas, Lea, Bruhn, Matthias, Graalmann, Lukas, Koster, Mario, Verboom, Murielle, Hallensleben, Michael, Guzmán, Carlos Alberto, Sutter, Gerd, Schmidt, Reinhold E, Witte, Torsten, Kalinke, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Rheumatoid Arthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600602/ https://www.ncbi.nlm.nih.gov/pubmed/34226189 http://dx.doi.org/10.1136/annrheumdis-2021-220435

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