Reduction of the Double Bond of 6-Arylvinyl-1,2,4-trioxanes Leads to a Remarkable Increase in Their Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in a Swiss Mice Model

[Image: see text] Novel 6-arylethyl-1,2,4-trioxanes6a–i and 7a–i are easily accessible in one step from the diimide reduction of 6-arylvinyl-1,2,4-trioxanes 5a–i. All of these new trioxanes were assessed for their oral antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis i...

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Detalles Bibliográficos
Autores principales: Hassam, Mohammad, Singh, Ajit Shankar, Yadav, Dinesh Kumar, Singh, Chandan, Puri, Sunil K., Verma, Ved Prakash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600630/
https://www.ncbi.nlm.nih.gov/pubmed/34805707
http://dx.doi.org/10.1021/acsomega.1c05041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600630/
https://www.ncbi.nlm.nih.gov/pubmed/34805707
http://dx.doi.org/10.1021/acsomega.1c05041

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