Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons

Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial and temporal control of gene expression. To overcome this,...

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Detalles Bibliográficos
Autores principales: Weber, Audrey J., Adamson, Ashley B., Greathouse, Kelsey M., Andrade, Julia P., Freeman, Cameron D., Seo, Jung Vin, Rae, Rosaria J., Walker, Courtney K., Herskowitz, Jeremy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600782/
https://www.ncbi.nlm.nih.gov/pubmed/34794469
http://dx.doi.org/10.1186/s13041-021-00878-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600782/
https://www.ncbi.nlm.nih.gov/pubmed/34794469
http://dx.doi.org/10.1186/s13041-021-00878-4

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