Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids

BACKGROUND: Tumor-specific cytotoxic T cells and T cell receptors are effective tools for cancer immunotherapy. Most efforts to identify them rely on known antigens or lymphocytes that have infiltrated into the tumor bed. Approaches to empirically identify tumor-targeting T cells and T cell receptor...

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Detalles Bibliográficos
Autores principales: Meng, Qingda, Xie, Shanshan, Gray, G Kenneth, Dezfulian, Mohammad H, Gandarilla, Omar, Li, Weilin, Huang, Ling, Akshinthala, Dipikaa, Ferrer, Elizabeth, Conahan, Catherine, Perea Del Pino, Sofia, Grossman, Joseph, Elledge, Stephen J, Hidalgo, Manuel, Muthuswamy, Senthil K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601084/
https://www.ncbi.nlm.nih.gov/pubmed/34789550
http://dx.doi.org/10.1136/jitc-2021-003213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601084/
https://www.ncbi.nlm.nih.gov/pubmed/34789550
http://dx.doi.org/10.1136/jitc-2021-003213

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