Reconstitution of a mini‐gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus

Salinomycin, an FDA‐approved polyketide drug, was recently identified as a promising anti‐tumour and anti‐viral lead compound. It is produced by Streptomyces albus, and the biosynthetic gene cluster (sal) spans over 100 kb. The genetic manipulation of large polyketide gene clusters is challenging, a...

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Detalles Bibliográficos
Autores principales: Li, Dong, Tian, Yuqing, Liu, Xiang, Wang, Wenxi, Li, Yue, Tan, Huarong, Zhang, Jihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601195/
https://www.ncbi.nlm.nih.gov/pubmed/33270372
http://dx.doi.org/10.1111/1751-7915.13686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601195/
https://www.ncbi.nlm.nih.gov/pubmed/33270372
http://dx.doi.org/10.1111/1751-7915.13686

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