Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction

SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound angiotensin-converting enzyme 2 (ACE2). The receptor binding motif (RBM), located within the S1 subunit of the spike protein, incorporates the majority of kn...

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Detalles Bibliográficos
Autores principales: Mahindra, Amit, Tejeda, Gonzalo, Rossi, Mario, Janha, Omar, Herbert, Imogen, Morris, Caroline, Morgan, Danielle C., Beattie, Wendy, Montezano, Augusto C., Hudson, Brian, Tobin, Andrew B., Bhella, David, Touyz, Rhian M., Jamieson, Andrew G., Baillie, George S., Blair, Connor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601423/
https://www.ncbi.nlm.nih.gov/pubmed/34793553
http://dx.doi.org/10.1371/journal.pone.0260283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601423/
https://www.ncbi.nlm.nih.gov/pubmed/34793553
http://dx.doi.org/10.1371/journal.pone.0260283

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